How Much Does a Physician Assistant Make in Mississippi in 2026?

A typical Physician Assistant in Mississippi earns about $50.92 per hour, or $105,920 per year, according to the latest government wage data (May 2025). Calculated from that annual figure, pay works out to roughly $8,827 a month and $2,037 a week. These numbers reflect typical pay across the profession in the state, not a starting salary or a maximum.

That typical pay sits 22% below the national figure of $135,880 a year ($65.33 an hour), according to the same data. Mississippi ranks 50th out of 51 states for Physician Assistant pay, among the lowest in the country. Lower pay here tracks a lower cost of living. About 320 Physician Assistants work in the state, versus 162,150 nationally.

Entry-level positions for Physician Assistants in Mississippi typically offer around $21.17 an hour, or about $44,030 a year, for those just starting out. Pay tends to rise from there as clinicians gain experience and take on more clinical responsibility. Within a few years, many reach the state's typical pay of $50.92 an hour. Starting pay varies by practice setting and supervising physician arrangements.

Experienced Physician Assistants in Mississippi often earn upwards of $63.79 an hour, or about $132,680 a year. The top 10% of earners make over $79.63 an hour, or $165,630 a year. That leaves a spread of $121,600 between entry-level and top-tier pay in the state. Practice setting, years of experience, and the city where a clinician works tend to separate the two ends of that range.

Mississippi's Physician Assistant pay has climbed sharply over the past decade. Pay rose from $33,660 in 2015 to $105,920 in 2025, a gain of $72,260, or 215%. The climb wasn't steady the whole way; pay dipped between 2020 and 2022 before recovering by 2024.

Nationally, Physician Assistant pay rose 38% over the same decade, far less than Mississippi's climb. Mississippi's percentage gain outpaced the national one by a wide margin, even though its dollar figures started and remain lower. Pay for the profession in Mississippi has moved up substantially for someone starting a career now, though past gains don't guarantee future ones.

Pay runs highest in Hattiesburg, where Physician Assistants earn $108,420 a year, about 2% above the statewide figure. Gulfport and Biloxi both post $105,920 a year, in line with the state as a whole. These figures cover each city's full metro area, not just the city limits.

Jackson pays the least among Mississippi's tracked cities, at $101,830 a year, though it's also home to the state's largest Physician Assistant workforce, with about 110 employed there. That's a spread of $6,590 between the highest- and lowest-paying cities in the state. Pay differences between Mississippi cities are modest compared with the cost-of-living differences a clinician might weigh when comparing job offers.

Mississippi pays Physician Assistants less than each of its bordering states. Louisiana leads the region at $128,870 a year, 22% higher than Mississippi, and Arkansas and Tennessee both pay around $118,300 to $118,430 a year, about 12% more. Alabama comes closest to Mississippi, at $104,960 a year, roughly 1% lower. A Physician Assistant license earned in Mississippi can often be endorsed or transferred into a neighboring state, though requirements vary.

Physician Assistants in Mississippi typically earn $105,920 a year, pay that has risen 215% since 2015 even though it remains below the national figure. Anyone considering the field in Mississippi can check the state licensing board's requirements for registration and scope of practice, and compare city-level figures for Hattiesburg, Jackson, Gulfport, and Biloxi before choosing where to practice.