How Much Does an NP Make in Mississippi in 2026?

A typical nurse practitioner in Mississippi earns about $59.96 per hour, or $124,730 per year, according to the latest government wage data (May 2025). That works out to roughly $10,394 a month and $2,399 a week, both figures calculated from the annual pay. Those numbers reflect nurse practitioners across all settings and experience levels statewide.

That typical pay sits 6% below the national figure of $132,300 a year ($63.61 an hour), ranking Mississippi 47th out of 51 states and the District of Columbia. Lower pay in Mississippi tends to track the state's lower cost of living compared with higher-paying regions. About 4,690 nurse practitioners worked in the state as of the latest count, a workforce large enough to shape these figures across cities and settings.

Entry-level positions for nurse practitioners in Mississippi typically offer around $47.49 an hour, or about $98,780 a year, according to the same May 2025 wage data. New NPs often start near this range while building clinical hours and employer trust. Within a few years, pay tends to move up toward the state's typical figure of $124,730 a year. Growth from there depends on setting, specialty, and location within the state.

Experienced nurse practitioners in Mississippi often earn upwards of $134,020 a year, and the top 10% of earners make over $156,830 a year ($75.40 an hour). That leaves a spread of $58,050 between entry-level and top-tier pay. Experience, practice setting, and city all play a part in where an individual NP lands within that range, along with the type of care delivered.

Nurse practitioner pay in Mississippi has risen steadily over the past decade, climbing from $95,240 in 2015 to $124,730 in 2025. That is a gain of $29,490, or 31%, over ten years. The increase came in stages rather than a straight line, including a dip in 2021 before pay resumed climbing through 2025.

Nationally, nurse practitioner pay rose 35% over the same decade, a slightly faster pace than Mississippi's climb. Mississippi's rate still outpaces general inflation, and pay has moved up in nine of the past ten years. For someone starting a career now, recent history points to a role where earnings have generally increased over time, though future results are not guaranteed.

Pay for nurse practitioners runs highest in Gulfport and Biloxi, tied as the top-paying metro areas in the state, where the typical NP earns $128,150 a year ($61.61 an hour). That is about 3% above the statewide figure of $124,730. These figures cover each metro area as a whole, not just the city center.

Hattiesburg pays the least among Mississippi's tracked metro areas, with a typical NP salary of $113,300 a year ($54.47 an hour), a spread of $14,850 between the highest- and lowest-paying cities. Jackson, the state capital metro area, employs the most nurse practitioners in Mississippi at 1,310 jobs, even though its pay sits close to the statewide figure. Higher-paying cities also tend to carry a higher cost of living, which offsets some of the difference.

Mississippi's nurse practitioner pay compares closely with next-door Arkansas, where the typical NP earns $125,660 a year, about 1% higher than Mississippi's figure. Alabama pays noticeably less, at $105,750 a year, about 15% below Mississippi. Louisiana and Tennessee fall in between, at $125,600 and $117,590. Nurse practitioner licenses can often be endorsed or transferred between neighboring states, which makes comparing regional pay useful for anyone considering a move.

Nurse practitioners in Mississippi typically earn $124,730 a year, a figure that has climbed 31% over the past decade. Pay runs somewhat below the national figure but varies by city, with Gulfport and Biloxi paying the most and Hattiesburg the least. Anyone considering a move should check Mississippi's licensing and registry requirements for nurse practitioners, and review city-level pages for local pay details before deciding where to practice.